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演講快訊
Bioengineering Approaches for Enhancing Therapeutic Efficacy of Cell Therapy
[2020/11/27]
教務
Bioengineering Approaches for Enhancing Therapeutic Efficacy of Cell Therapy

時間

20201127 () 15:10 PM    主持人:游聲盛老師

                                                發佈人:謝馨瑩

講者

黃玠誠 教授

服務單位

清華大學生物醫學工程研究所

講題

Bioengineering Approaches for Enhancing Therapeutic Efficacy of Cell Therapy

地點

華立廳

語言

中文

摘要

Cell transplantation has been demonstrated to be a promising therapy for treating various diseases and injuries. In conventional cell therapies, cells are trypsinized, harvested, and transplanted into the lesion area. However, massive cell loss may occur owing to mechanical leakage, cell detachment-associated anoikis, or the hostile microenvironment in target tissue, thus limiting the ultimate therapeutic capacity. Herein, we aim to enhance the retention, survival, and pro-regenerative capacities of the engrafted cells by (i) assembling them into three-dimensional (3D) spheroids and (ii) modulating the microenvironment of the target area using functional biomaterials. Our in vitro and in vivo results demonstrate that transplanting cells in 3D-spheroid configuration that comprise of cells and the deposited matrices and growth factors provides a superior therapeutic effect than that of simple cell suspension. Moreover, the developed functional biomaterials help establish a suitable microenvironment for the engrafted cells to survive and conduct regeneration. Therefore, we anticipate that the proposed approaches can offer promising means to enhance the therapeutic efficacy of cell transplantation.

 

學經歷

學歷:

國立清華大學化學工程系博士 2015

國立清華大學化學工程系碩士 2010

國立清華大學生命科學系學士2008

 

經歷:

國立清華大學化學工程系 博士後研究員

加拿大多倫多大學心臟血管外科研究中心 博士後研究員

國立清華大學生物醫學工程研究所 助理教授(2017/2迄今)

 


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