演講快訊

2021
04.23

Single Cell Derived Organoids Toward Precision Medicine

張瑛芝 教授

時間:2021年04月23日 (五) 13:10 PM
主持人:吳意珣 教授
講者:張瑛芝 教授
服務單位:中央研究院 基因體研究中心
講題:Single Cell Derived Organoids Toward Precision Medicine
地點:華立廳

摘要 :

To study cellular responses in relation to the microenvironments, we have constructed a series of zwitterionic polymeric films and extracellular matrix protein conjugated lipid bilayer as the biomimetic cell culture platforms. In this talk, I will present the strategy of tunable materials design intending to closely mimic the in vivo microenvironment of cells. We identified a series of surface constructs, R3CE platform (Rapid, Rare Cell 3D Expansion) which could induce and maintain stemness of the cells, subsequently leading to single cell derived 3D spheroid within days. Clinical studies have indicated that extremely low abundant cells, such as primary tissues, circulating tumor cells, and stem cells, can be expanded to sufficient quantity for the subsequent multiomic molecular analysis and in vitro drug testing - an important step toward precision medicine.

學經歷 :

B.S., Chemical Engineering, National Taiwan University, Taipei, Taiwan

Ph.D., Chemical Engineering, Stanford University, CA, 1998

 

Senior Engineer: Department of Advanced Technology, MMC (Maxtor Corp.), San Jose, CA, USA, 1998

Postdoctoral Scientist, Stanford University, CA/ Affymetrix Corp, Santa Clara, CA, USA, 1998-1999

Assistant Professor, Department of Chemical Engineering and Materials Science, and Department of Biomedical Engineering, University of California, Irvine, USA, 1999-2003

Associate Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2004-2007

Professor, Genomics Research Center, Academia Sinica, Taipei, Taiwan, 2010-present

Adjunct Professor, Department of Chemical Engineering, Stanford University, USA, 2016-present