演講快訊

2022
04.22

Substrate-controlled Enzymatic Glycosylation for Complex Oligosaccharide Synthesis

游景晴 教授

時間:2022年04月22日 (五) 13:10 PM
主持人:柯碧蓮 教授
講者:游景晴 教授
服務單位:國立中正大學 化學暨生物化學系
講題:Substrate-controlled Enzymatic Glycosylation for Complex Oligosaccharide Synthesis
地點:93406

摘要 :

My laboratory focuses on the synthesis of human milk oligosaccharides (HMOs). The use of enzymatic strategies for glycan synthesis not only provides better control of stereoselectivity but also avoids multistep synthetic manipulations required by chemical approaches to complex carbohydrate synthesis. These biologically important HMOs will serve as essential probe molecules and/or nutrient resources to explore the interaction of HMOs with human gut microbiota. This work has applications in vaccine development and drug discovery. A major contribution from my lab is the development of a sequential one-pot enzymatic synthesis system using a panel of glycosyltransferases (GTs) and sugar-nucleotides generating enzymes, which has allowed the facile preparation of a library of HMOs (~100 glycans). This is one of the largest collections of this type in the work and importantly we have made these compounds in quantities that facilitate a large number of biological studies.

 

學經歷 :

彰化師範大學化學系理學士 (2005)

國立清華大學化學系碩士 (2007)

國立清華大學化學系博士 (2012)

 

日本大阪大學訪問研究員 (2010)

加拿大英屬哥倫比亞大學訪問研究員 (2011-2012)

國立清華大學化學系博士後研究員 (2013)

加拿大英屬哥倫比亞大學博士後研究員 (2014-2015)

中正大學化學暨生物化學系助理教授 (2015-2020)

國立中正大學化學暨生物化學系副教授 (2020-)

中央研究院生物化學研究所合聘副研究員 (2021-)