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Personal Profile
Associate Professor  Chen, Mei-Chin
Office: 93912 Specialty:
Tel. Ext.:
62696
Fax:
(06)-2344496
E-mail:
Web Site:
Education

Ph.D., Chemical Engineering, 9/2004 - 7/2008 National Tsing Hua University, Hsinchu, Taiwan.
M. Sc., Chemical Engineering, 9/2002 - 7/2004 National Tsing Hua University, Hsinchu, Taiwan.
B.Sc., Chemical and Materials Engineering, 9/1998 - 6/2002 National Central University, Taiwan.

Experience

8/2013- Associate Professor: National Cheng Kung Univ., Tainan, Taiwan.

8/2009-7/2013 Assistant Professor: National Cheng Kung Univ., Tainan, Taiwan.

8/2008-7/2009 Research Fellow: National Tsing Hua Univ., Hsinchu, Taiwan.

Research

 

A-1. SCI Papers: the last 5 Years

 

(表列SCI impact factor 為2015年資料)

 

(1) Su, L.-C., Chen, M.-C.*, “Efficient Delivery of Nanoparticles to Deep Skin Layers using Dissolvable Microneedles with an Extended-Length Design,” Journal of Materials Chemistry B, 2017. (SCI 4.872, MATERIALS SCIENCE, BIOMATERIALS, 4/33) accepted.

 

(2) Hsueh, K.-J., Chen, M.-C., Cheng, L.-T., Lee, J.-W., Chung, W.-B., Chu, C.-Y.*, “Transcutaneous Immunization of Streptococcus suis Bacterin using Dissolving Microneedles,” Comparative Immunology, Microbiology and Infectious Diseases, vol. 50, pp. 78-87, 2017. (SCI 1.943, VETERINARY SCIENCES, 17/138)

 

(3) Chen, M.-C.*, Chan, H.-A., Ling, M.-H., Su, L.-C., “Implantable Polymeric Microneedles with a Phototriggerable Property as a Patient-Controlled Transdermal Analgesia System,” Journal of Materials Chemistry B, vol. 5, pp. 496-503, 2017. (SCI 4.872, MATERIALS SCIENCE, BIOMATERIALS, 4/33).

 

(4) Chen, M.-C.*, Lin, Z.-W., Ling, M.-H., “Near-Infrared Light-Activatable Microneedle System for Treating Superficial Tumors by Combination of Chemotherapy and Photothermal Therapy,” ACS Nano, vol. 10, pp. 93-101, 2016. (SCI 13.334, MATERIALS SCIENCE, MULTIDISCIPLINARY, 9/271).

 

(5) Chen, M.-C.*, Ling, M.-H., Kusuma, S.-J., “Poly-g-glutamic Acid Microneedles with a Supporting Structure Design as a Potential Tool for Transdermal Delivery of Insulin,” Acta Biomaterialia, vol. 24, pp. 106-116, 2015. (SCI 6.008, Engineering, Biomedical, 3/76)

 

(6) Chen, M.-C.*, Ling, M.-H., Wang, K.-W., Lin, Z.-W., Lai, B.-H., Chen, D.-H.*, “Near-Infrared Light-Responsive Composite Microneedles for On-demand Transdermal Drug Delivery,” Biomacromolecules, vol. 16, pp. 1598-1607, 2015. (SCI 5.583, Polymer Science, 5/85) (EI)

 

(7) Ko, P.-T., Lee, I.-C., Chen, M.-C., Tsai, S.-W.*, “Polymer Microneedles Fabricated from PCL and PCL/PEG Blends for Transdermal Delivery of Hydrophilic Compounds,” Journal of the Taiwan Institute of Chemical Engineers, vol. 51, pp. 1-8, 2015. (SCI 2.848, Engineering, Chemical, 24/135)

 

(8) Chen, M.-C.*, Wang, K.-W., Chen, D.-H., Ling, M.-H., Liu, C.-Y., “Remotely Triggered Release of Small Molecules from LaB6@SiO2-loaded Polycaprolactone Microneedles,” Acta Biomaterialia, vol. 13, pp. 344-353, 2015. (SCI 6.008, Engineering, Biomedical, 3/76)

 

(9) Su, L.-C., Chen, Y.-H.*, Chen, M.-C.*, “Dual Drug-eluting Stents Coated with Multi-layers of Hydrophobic Heparin and Sirolimus,” ACS Applied Materials & Interfaces, vol. 5, pp. 12944-12953, 2013. (SCI 7.145, Materials Science, Multidisciplinary, 25/271) (EI)

 

(10) Ling, M.-H., Chen, M.-C.*, “Dissolving Polymer Microneedle Patches for Rapid and Efficient Transdermal Delivery of Insulin to Diabetic Rats,” Acta Biomaterialia, vol. 9, pp. 8952-8961, 2013. (SCI 6.008, Engineering, Biomedical, 3/76)

 

(11) Chen, M.-C.*, Huang, S.-F., Lai, K.-Y., Ling, M.-H., “Fully Embeddable Chitosan Microneedles as a Sustained Release Depot for Intradermal Vaccination,” Biomaterials, vol. 34, pp.3077-3086, 2013. (SCI 8.387, Engineering, Biomedical, 2/76) (EI)

 

(12) Chen, M.-C.*, Sun, Y.-C., Chen, Y.-H., “Electrically Conductive Nanofibers with Highly Oriented Structures and their Potential Application in Skeletal Muscle Tissue Engineering,” Acta Biomaterialia, vol. 9, pp.5562-5572, 2013. (SCI 6.008, Engineering, Biomedical, 3/76)

 

(13) Chen, M.-C., Mi, F.-L., Liao, Z.-X., Hsiao, C.-W., Sonaje, K., Chung, M.-F., Hsu, L.-W., Sung, H.-W.*, “Recent Advances in Chitosan-based Nanoparticles for Oral Delivery of Macromolecules,” Advanced Drug Delivery Reviews, vol. 65, pp.865-879, 2013. (SCI 15.606, Pharmacology & Pharmacy, 3/253) (EI)

 

(14) Chen, M.-C.*, Ling, M.-H., Lai, K.-Y., Pramudityo, E., “Chitosan Microneedle Patches for Sustained Transdermal Delivery of Macromolecules,” Biomacromolecules, vol. 13, pp.4022-4031, 2012. (SCI 5.583, Polymer Science, 5/85) (EI) 

 

 

 

A-2. 技術期刊

 

1.  邱鈺琇,陳美瑾*, “經皮免疫新策略:可無痛標的傳輸疫苗之高分子微針貼片,” 化工, 第62卷, pp. 71-83, 2015.

 

2.  蘇良晟,陳美瑾*, “心血管支架之發展與未來展望,” 化工月刊, 2014年8月號, pp. 56-80, 2014.

 

3.  蘇良晟, 陳美瑾*, “具抗凝血與抗血管內膜增生之雙效型藥物釋放血管支架,”界面科學會誌, 第32卷, pp.10-18, 2010.

 

4.  陳美瑾*, “大分子藥物之經皮傳輸新利器—無痛式高分子微針貼片,” 化學, 第68卷第3期, pp.215-223, 2010.

 

5.   陳美瑾*, 陳俊宏, 宋信文, “膠原蛋白及其於生醫材料與醫療器材上的應用,” 化工技術, 第176期, pp.168-180, 2007.

 

 

 B. Conference Papers

 

1.  Chen, M.-C.*, Lin, Z.-W., “Synergistic Effect of Chemo-Photothermal Therapy using Remotely Triggerable Polymer Microneedles,” Program of MNC 2015-28th International Microprocesses and Nanotechnology Conference, 2015. (11/9~11/13)  

 

2.  Chen, Y.-Y.*, Chen, S.-Y., Chen, M.-C.* “Embeddable Polymeric Microneedles as a Sustained Delivery System of Goserelin for Prostate Cancer Treatment,” Program of MNC 2015-28th International Microprocesses and Nanotechnology Conference, 2015. (11/9~11/13)

 

3. 陳佳穗、賴冠穎、陳美瑾*,“貼片可溶式鑲嵌型微針作為新一代經皮疫苗緩釋系統,” 2015生物醫學工程科技研討會暨科技部醫學工程學門成果發表會。獲得壁報論文競賽特優獎。

 

4.  Chen, M.-C.*, Lin, Z.-W., “Light Triggerable Polymer Microneedles for Chemo-Photothermal Synergistic Cancer Therapy,” 2015台灣化學工程學會62週年年會暨科技部化工學門成果發表會。(2015/11/6) 邀請演講

 

5.  凌銘鴻、陳美瑾*, “可長效經皮釋放胰島素之幾丁聚醣微粒方體,” 2015幾丁質幾丁聚醣暨生物材料研討會,會議手冊,pp. 146。榮獲壁報論文競賽佳作獎。(9/11)

 

6. 陳怡穎、陳淑媛、陳美瑾*, “可長效釋放賀爾蒙之鑲嵌式幾丁聚醣微針應用於前列腺癌治療,” 2015幾丁質幾丁聚醣暨生物材料研討會,會議手冊,pp. 159-161。榮獲壁報論文競賽佳作獎。(9/11)

 

7.  陳美瑾*, “Designing Polymeric Microneedle Patches for Rapid, Sustained, and On-demand Transdermal Drug Delivery,” 2015奈米元件技術研討會會議手冊,pp. 16,2015。(2015/09/10) 邀請演講

 

8.  凌銘鴻、李岳璋、陳美瑾*, “糖尿病免挨針:可長效經皮釋放胰島素之幾丁聚醣微粒方體,”2015生醫機電與臨床創意設計、製作競賽。獲得創意獎。(2015/5/15)

 

9. 蘇良晟、陳美瑾*,“有效經皮傳輸含藥奈米粒子之快溶型微針貼片,” 第八屆國際儀器展( 2015 KIIS)。獲得研究論文壁報比賽佳作。(2015/5/27)

 

10.  Chen, M.-C.*, Lin, Z.-W., “Near-infrared Light Triggerable Polymer Microneedles for Chemo-Photothermal Synergistic Cancer Therapy,” Program book of 2015 The 5th Asian Biomaterials Congress, pp. 20, 2015. Best Young Investigator Oral Presentation Award (5/6~5/9)

 

11.  Chen, M.-C.*, “Design of Polymeric Microneedle Patches for Rapid, Sustained, and On-demand Transdermal Drug Delivery,” Program book of 2015 The 5th Asian Biomaterials Congress, pp. 33, 2015. (5/6~5/9)

 

12.  Chen, Y.-Y., Chen, M.-C.*, Chen, S.-Y., “Chitosan Microneedles with Patch-dissolvable Design as a Sustained Hormone Release System for the Treatment of Prostate Cancer,” Program book of 2015 The 5th Asian Biomaterials Congress, pp. 31, 2015. Best Student Poster Award

 

13.  Su, L.-C., Chen, M.-C.*, “Dissolving Microneedle-enhanced Delivery of Drug Loaded Nanoparticles into the Skin,” Program book of 2015 The 5th Asian Biomaterials Congress, pp. 29, 2015. Best Student Poster Award

 

14. 丁一釗、詹皓安、陳美瑾*,“遙控驅動釋放型高分子微針做為新一代病患自控式止痛系統,” 2015年中華民國高分子學會年會暨論文發表會會議手冊, pp 49, 2015. 獲得壁報論文競賽佳作獎。

 

15.  Hsueh, K.-J., Chen, M.-C., Chung, W.-B., Chu, C.-Y., “Development of Novel Type of Porcine Bacterin,” 中華民國獸醫學會暨台灣省畜牧獸醫學會103年度聯合年會暨學術論文發表會會議手冊, pp. 33, 2014. 獲得口頭論文獎優勝。(2014/12/06)

 

16.   Chen, M.-C.*, “Fully Embeddable Chitosan Microneedles as a Sustained Release Depot for Intradermal Vaccination,” Proceeding of 2014 Young Asian Biochemical Engineerings’ Community (YABEC), pp. 22, 2014. (2014/11/6-8,中正大學) Keynote Speaker

 

17.  Chen, M.-C.*, “New Immunization Strategy: Embeddable Chitosan Microneedles for Sustained Transdermal Vaccine Delivery,” 2014海峽兩岸高分子學術研討會, pp. 34, 2014. (2014/10/18-21,青島) Invited Lecture

 

18.  Su, L.-C., Chen, M.-C.*, “Rapid and Efficient Transdermal Delivery of Drug-loaded Nanoparticles using Dissolving Polymer Microneedles,” Proceeding of 2014 International Symposium on Nano Science and Technology, pp. 154, 2014. 獲得壁報論文競賽佳作獎。(2014/10/17)

 

19.  Chen, M.-C.*, Lin, Z.-W., “Near-infrared Light Responsive Composite Microneedles for Chemo-Photothermal Synergistic Cancer Therapy,” Proceeding of the 15th IUMRS-International Conference in Asia (IUMRS-ICA 2014), pp. 73, 2014. (2014/08/24-30, Fukuoka)

 

20.  蘇良晟、陳美瑾*,“可快速有效經皮傳輸含藥奈米粒子之快溶型高分子微針貼片,”2014年中華民國界面科學學會年會暨論文發表會會議手冊, pp. 63, 2014. 獲得壁報論文競賽優等獎。(2014/07/11)

 

21.  陳淑媛、陳佳穗、陳美瑾*,“可鑲嵌式幾丁聚醣微針於經皮緩釋人類生長激素之應用,” 2014年中華民國界面科學學會年會暨論文發表會會議手冊, pp. 109, 2014. 獲得壁報論文競賽佳作獎。(2014/07/11)

 

22.  賴冠穎、林佶民、陳淑媛、陳美瑾*,“鑲嵌式幾丁聚醣微針做為新一代經皮緩釋疫苗劑型,” 2014年生醫材料及藥物制放研討會暨海峽兩岸生醫材料及藥物制放研討會論文集. 獲得壁報論文競賽特優獎。(2014/05/02)

 

23.  林致緯、鍾覲羽、陳美瑾*,“結合化療及光熱療之光驅動釋放型微針於腫瘤治療之應用,” 2014年生醫材料及藥物制放研討會暨海峽兩岸生醫材料及藥物制放研討會論文集. 獲得壁報論文競賽優等獎。(2014/05/02)

 

24.  陳美瑾*“免疫新策略:經皮緩釋疫苗之幾丁聚醣微針貼片,” 2014年生醫材料及藥物制放研討會暨海峽兩岸生醫材料及藥物制放研討會.Invited Lecture

 

25.  林佶民、賴冠穎、陳淑媛、陳美瑾*,“經皮緩釋流感疫苗之鑲嵌式幾丁聚醣微針,” 2014年中華民國高分子學會年會暨論文發表會會議手冊, pp. 314, 2014.獲得2014年中華民國高分子學會年會壁報論文競賽佳作獎。

 

26.  Chen, M.-C.*, Lai, K.-Y., “Sustained Delivery of Vaccine from Patch-dissolvable Chitosan Microneedles for Transcutaneous Immunization,”Proceeding of the ACSIN-12 & ICSPM21, pp. 54, 2013.

 

27.  賴冠穎、陳美瑾*,“可長效釋放疫苗之貼片可溶式幾丁聚醣微針:無痛、緩釋型疫苗貼片,” 第三屆全研科技論文獎競賽, 2013. 獲得優良創意作品獎.

 

28.  Chen, M.-C.*, Lai, K.-Y., “Sustained Transdermal Delivery of Antigens using Embeddable Chitosan Microneedles for Intradermal Vaccination,” Proceeding of the 2013 Asian Symposium on Advanced Materials, pp. 53, 2013. Invited Lecture.

 

29.  Chan, H.-A., Lin, Z.-W., Chen, M.-C.*, “Triggerable Polymeric Microneedles for Chemo-Photothermal Cancer Therapy,” Proceeding of the 2013 Asian Symposium on Advanced Materials, pp. 126, 2013. Best Poster Award.獲得2013年亞洲先進材料研討會最佳海報論文獎。

 

30. 賴冠穎、陳美瑾*,“緩釋疫苗之貼片可溶式幾丁聚醣微針於經皮免疫之應用,” 2013年中華民國界面科學學會年會暨論文發表會會議手冊, pp. 57, 2013. 此篇論文獲得2013年中華民國界面科學學會年會暨論文發表會傑出海報獎。

 

31. 林致緯, 陳美瑾*, "近紅外光驅動釋放型微針於癌症化療及光熱協同治療之應用, "2013年中華民國界面科學學會年會暨論文發表會議事手冊, p.37.

 

32.  Ling, M.-H., Pramudityo Esar, Lai, K.-Y., Chen, M.-C.*, “Biodegradable Chitosan Microneedle Patches for Sustained Transdermal Delivery of Biomacromolecules,” Proceeding of the 9th SPSJ International Polymer Conference (IPC 2012), pp. 586, 2012.

 

C. Patents

 

(1).  Sung, H.-W., Chen, M.-C., Tu, P., and Tu, H., “Drug-eluting Stent having Collagen Drug Carrier Chemically Treated with Genipin,” U.S. Patent No. 7,351,421, 4/1/2008.

 

(2).  Sung, H.-W., Chen, M.-C., Lee, P.-W., and Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means,” U.S. Patent No. 7,449,200, 11/11/2008.

 

(3).  Sung, H.-W., Chen, M.-C.Lin, Y.-H., Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,541,046 B1, 6/2/2009.

 

(4).  Sung, H.-W., Lin, Y.-H., Chen, M.-C., and Tu, H., “Nanoparticles for Monoclonal Antibody Delivery,” U.S. Patent No. 7,541,028 B2, 6/2/2009.

 

(5). Sung, H.-W., Chen, M.-C.Lin, Y.-H., Liang, H.-F., and Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,858,596 B2, 12/28/2010.

 

(6). Sung, H.-W., Lin, Y.-H., Chen, M.-C., and Tu, H., “Nanoparticles for Drug Delivery,” U.S. Patent No. 7,879,361 B2, 2/1/2011.

 

(7). Sung, H.-W., Chen, M.-C., Lee, P.-W., Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means Thereof,” U.S. Patent No. 7,901,711 B1, 3/8/2011.

 

(8). Sung, H.-W., Chen, M.-C.Lin, Y.-H., Liang, H.-F., and Tu, H., “Nanoparticles for Protein Drug Delivery,” U.S. Patent No. 7,919,293 B2, 4/5/2011.

 

(9). Sung, H.-W., Chen, M.-C., Tu, H., “Nanoparticles for targeting hematoma cells and delivery means,” U.S. Patent No. 7,985,426 B1, 7/26/2011.

 

(10). Sung, H.-W., Chen, M.-C., Lee, P.-W., Tu, H., “Nanoparticles for Protein/Peptide Delivery and Delivery Means Thereof,” U.S. Patent No. 8,137,697 B1, 3/20/2012.

 

(11). Sung, H.-W., Chen, M.-C., and Tu, H., “Delivery Means for Drug-eluting Biodegradable Stent,” 美國專利 (USPTO 11/024,101, filed on 12/28/2004). Claims Allowed & Fee Paid.

 

(12). Sung, H.-W, Chen, M.-C.Tu, P., and Tu, H., “Drug-Eluting Biodegradable Stent“ 美國專利 (USPTO 10/916,170, filed on 8/11/2004)

 

(13). Sung, H.-W., Chen, M.-C., and Tu, H., “Delivery Means for Drug-eluting Biodegradable Stent,” 美國專利 (USPTO 11/048,589, filed on 2/1/2005).

 

(14). Sung, H.-W., Chen, M.-C., and Tu, H., “Drug-eluting Biodegradable Stent,” 美國專利 (USPTO 11/130,787, filed on 5/17/2005).

 

(15). Sung, H.-W., Chen, M.-C., and Tu, H., “Biodegradable Occlusive Device with Moisture Memory,” 美國專利(USPTO 11/180,498, filed on 7/12/2005).

 

(16). Sung, H.-W., Chen, M.-C., and Tu, H., “Medical Device with Living Cell Sheet,” 美國專利 (USPTO 11/412,610, filed on 4/27/2006).

 

(17). Sung, H.-W., Lin, Y.-H., Chen, M.-C., Tu, H., “Nanoparticles for Drug Delivery,” 美國專利 (USPTO 12/008,556, filed on 1/11/2007)

 

(18). 陳美瑾、陳東煌、王冠雯、賴柏宏,“經皮藥物釋放貼片及利用近紅外光控制其藥物釋放之方法”中華民國專利號數TW I458504 B,公告日11/1/2014)。microneedle's patent

 

(19). Chen, M.-C.,Chen, D.-H., Wang, K.-W., Lai, B.-H., “Transdermal Drug Delivery Patch and Method of Controlling Drug Release of the Same by Near-IR,” U.S. Patent No. 8,834,447 B2, 9/16/2014. microneedle's patent

 

(20) 陳美瑾、黃詩方,“鑲嵌式經皮藥物釋放貼片及其製造方法”中華民國專利證書發明第I554289,專利權期間自2016年10月21日至2032年6月28日止。microneedle's patent

 

(21). Chen, M.-C.,Huang, S.-F., “Embeddable Microneedle Patch for Transdermal Drug Delivery and Method of Manufacturing the Same,” 美國專利 (USPTO 13/610,203, filed on 9/11/2012)microneedle's patent

 

(22). 陳美瑾、賴冠穎、林駿崴、凌銘鴻,“微針經皮傳輸裝置及應用其之微針經皮傳輸方法”中華民國專利中華民國專利證書發明第I528975,專利權期間自2016年4月11日至2033年7月11日止. microneedle's patent

 

(23).  Chen, M.-C.Lai, K.-Y., Lin, C.-W., Ling, M.-H., “Substance Delivery Device and Substance Delivery Method using the Same,” 美國專利 (USPTO 14/328,571, filed on 7/10/2014). microneedle's patent  

 

D. 學術榮譽

 

1. 2011年6月獲選為「成功大學工學院明日之星」

 

2. 2013年12月獲得臺灣綜合大學系統「年輕學者創新研究選拔」之傑出獎

 

3. 2015年5月獲得104年度李昭仁教授生醫工程「年輕學者獎」

 

4. 2015年5月獲得Best Young Investigator-Oral Presentation Award in the 5th Asian Biomaterials Congress

 

5. 2015年11月參加科技部工程司104年度先導開發型產學合作計劃化材民生領域成果發表暨績效考評會議榮獲海報展示傑出獎

 

 

 

E. 指導學生參與非研討會競賽得獎

 

1. 專題生-周宛璇獲得「科技部100年度大專生研究計劃研究創作獎」

 

2. 專題生-陳玟璇獲得「科技部103年度大專生研究計劃研究創作獎」(104/8/5)

 

 

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