演講快訊
- /
- 本系公告 /
- 演講快訊
03.05
Metallo-elastomers, the promises and the challenges
Professor Yadong Wang
摘要 :
Why: Metal ions are critical for the beginning, growth, and homeostasis of life. Many proteins cease to function without metal ions. However, application of metals in biomaterials has been limited to metallic alloys and crosslinked alginate hydrogels.
How: We designed a series of tough elastomers using various metal ions as crosslinkers while simultaneously utilizing the inherent bioactivities of metal ions to guide the cell and host response. Rapid chelation of metal ions and polymeric ligands form network polymers with unique properties.
So what: This concept leads to a huge leverage of mechanical and biological activities attainable in the resultant polymers. I will use copper to illustrate the power of this design philosophy. The copper crosslinked elastomer is proangiogenic, anti-oxidative, and catalyzes the generation of nitric oxide in the presence of plasma. My research group is exploring the application of this and other metallo-elastomers in medicine.
學經歷 :
Yadong Wang is the inaugural McAdam Family Foundation Professor at Cornell University. He obtained his Ph.D. degree under the guidance of Daniel Stack at Stanford University in 1999, conducted his postdoctoral research at the Langer Lab at MIT, and joined the Georgia Institute of Technology in 2003 as an assistant professor. He was recruited to the University of Pittsburgh in 2008 and to Cornell in 2017. He has published on topics ranging from Chemistry, Materials Science to Biomedical Engineering. He is a fellow of American Institute for Medical and Biological Engineering and the National Academy of Inventors. His research focuses on the design and application of biomaterials. Several of his inventions are licensed and commercialized for clinical use.